The anti-proliferative effect of CBD was cannabinoid and vanilloid receptors independent. The CB2 receptor antagonist SR reverted the. Several studies have demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids . To determine the effects of CBD on cell proliferation, the [3-(4. Δ9-THC, cannabidiol (CBD) and cannabinol (CBN) are the most prevalent . Cannabinoids have been proved to be anti-proliferative and.
is Proliferative CBD Anti
Relative involvement of cannabinoid and vanilloid receptors. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.
Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics. American journal of physiology. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes.
An international land mark study titled: In that study, researchers provide an overview of the recent pharmacological advances, mechanisms of action, and potential therapeutic applications of cannabinoids. In this study, special emphasis was given to cannabidiol CBD for possible applications for inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to D9 tetrahydrocannabivarin THCV, a novel CB1 antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity.
CBDA was the least effective compound, being active against only breast, thyroid and glioma cells. Furthermore, prostate carcinoma cells were found to be quite resistant to the action of phytocannabinoids, with only CBD and CBG exerting anti-proliferative effects .
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Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.
Influence of selective receptor antagonists on CBD antiproliferative action. MDA- MB cells were treated with 10 M cannabidiol in presence or in absence of . Antiproliferative effects, evaluated by MTT assay, of cannabidiol (CBD, 10 μ M, 24 h-exposure) alone or in the presence of rimonabant ( μ M) and AM (1 μ. CBD is a powerful anti-epileptic, anti-depressant, anti-inflammatory, anti- nauseate, sleep aid, muscle relaxant, sedative and anti-proliferative.