There are a number of studies supporting the efficacy of medical cannabis in eliminating nausea, appetite loss and other HIV/AIDS related. HIV/AIDS and Medical Cannabis. Recent studies have found that medical cannabis is effective in treating the symptoms caused by HIV/AIDS. The experience of patients, medical professionals and research has revealed that cannabis can safely treat a remarkably broad range of medical conditions.
Research Medicinal Cannabis – HIV AIDS
By stimulating activation of CB2 with cannabinoid receptor antagonists, Mount Sinai researchers decreased the ability of HIV to infect cells that utilize CXCR4, reducing the frequency of infected cells by 30 to 60 percent.
Cannabinoids may help prevent neurocognitive disorders Research conducted at Temple University School of Medicine and published in the Journal of Leukocyte Biology suggests that compounds that stimulate CB2 on macrophages may weaken HIV infection.
CB2 is the binding site for cannabinoids on macrophages, and stimulation of these receptors, unlike CB1, does not produce the euphoric effects associated with cannabis use. Neurocognitive disorders are common in people with HIV even in the presence of a strong immune response and suppressed viral load.
The virus establishes itself in the central nervous system early on in HIV infection and maintains a stronghold throughout the course of disease. Most antiretroviral medications are unable to cross the blood-brain barrier and thus cannot decrease the level of HIV in the brain, allowing for cognitive damage to continue.
Macrophages are long-lived cells that are targeted by HIV and exist throughout the body. Macrophages are present in the blood and all organs, including in the brain.
Some researchers hypothesize that these cells may be key to ongoing replication that creates inflammation, a damaging effect of overstimulation of the immune system. Inflammation can greatly contribute to many non-AIDS-related illnesses, such as neurocognitive disorders, cardiovascular disease, bone disease, and some forms of cancer.
The study authors found that anti-inflammatory compounds related to THC bind to CB2, effectively reducing viral replication and inflammation in the brain. Will this weakening have any negative health consequences? Future studies need to pay attention to these and the following issues:.
Programming Connection case study: De-simplifying single-tablet regimens for HIV treatment. Prevention in Focus Insufficient food linked to inflammation in HIV-positive women. Request for Proposal RFP: Production of this Web site has been made possible through a financial contribution from the Public Health Agency of Canada. We comply with the HONcode standard for trustworthy health information: Please note that some content on this website contains language, information and images related to sexuality and drug use, and may not be intended for people of all ages.
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Jump to Navigation Jump to Content. Hepatitis C Subscriptions Become a Member. See all issues of TreatmentUpdate Subscribe. Some research issues with marijuana, HIV and inflammation. Inflammation and immune activation in general When cells of the immune system discover the presence of an invading microbe or tumour, a normal response is to mobilize the rest of the immune system.
Inflammation and immune activation with HIV Chronic HIV infection is associated with excessive levels of inflammation and activation of the immune system. Researchers are concerned that chronic HIV-related inflammation and immune activation may, over the long-term, contribute to an increased risk for the following conditions: Marijuana and HIV Most of the studies done with herbal marijuana as opposed to pharmacological preparations or extracts in people with HIV have not been robustly designed.
Cannabinoids and the immune system—a possible point of intervention Lab experiments with cells of the immune system have found that when these cells become activated they display a relatively high density of receptors for cannabinoids. Bear in mind As mentioned earlier, the vast majority of studies with herbal marijuana and HIV-positive people have been observational in nature.
Future studies need to pay attention to these and the following issues: Which strains of marijuana were used? What was the relative mix of cannabinoids in such strains? How was marijuana used—smoked, ingested edibles or vapourized? How much marijuana was used and how often? Are there differences in the effect of marijuana by gender? The lymph node in HIV pathogenesis. Rapid inflammasome activation following mucosal SIV infection of rhesus monkeys.
Multiple origins of virus persistence during natural control of HIV infection. HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim. Immunologic biomarkers, morbidity and mortality in treated HIV infection. Journal of Infectious Diseases. Persistent HIV-1 replication maintains the tissue reservoir during therapy. Defining total-body AIDS-virus burden with implications for curative strategies.
Gut epithelial barrier and systemic inflammation during chronic HIV infection. T-cell activation independently associates with immune senescence in HIV-infected recipients of long-term antiretroviral treatment. Suboptimal adherence to combination antiretroviral therapy is associated with higher levels of inflammation despite HIV suppression.
Ageing and inflammation in patients with HIV infection. Clinical and Experimental Immunology. Mamik MK, Power C. Inflammasomes in neurological diseases: Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.
Association of arterial and lymph node inflammation with distinct inflammatory pathways in human immunodeficiency virus infection. Endocannabinoid system acts as a regulator of immune homeostasis in the gut.
Cardiovascular effects of marijuana and synthetic cannabinoids: Journal of Acquired Immune Deficiency Syndromes. Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed-type hypersensitivity. European Journal of Immunology.
Journal of Molecular Medicine. Turning over a new leaf: Cannabinoid and endocannabinoid modulation of immune function. Journal of Neuroimmune Pharmacology. Croxford JL, Yamamura T. Cannabinoids and the immune system: Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription.
How Does Marijuana Affect People With HIV?
In many ways, the progress of modern cannabinoid medicine has its roots in According to amfAR, the Foundation for AIDS Research. Get information on prevention, symptoms, and treatment to better ensure a long and Research Supporting Marijuana in Treating HIV Wasting. book on the history of the medical marijuana movement. litical prowess of AIDS activists and the frustrations of AIDS researchers had a profound effect on.