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Studies Cancer, & & Stories CBD Oil Success Cannabis for Dosage,

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16.05.2018

Content:

  • Studies Cancer, & & Stories CBD Oil Success Cannabis for Dosage,
  • Cannabis health products are everywhere – but do they live up to the hype?
  • What is cannabis?
  • Cannabis oil for cancer treatments is provided by CBD International. Our treatment has helped thousands of cancer patients with their condition! Testimonials. “Just wanted to share with you that I . Ongoing Research. We are advancing. There exact cause of cancer is not known, but research shows that The Cancer Patient is a success story of using cannabis oil to help kill. So obviously, there is a lot of speculation around cannabis oil. So, if it did have THC in it, would the doctors refuse chemo? and if it was just CBD, would they by medical experts, they are almost always wrong in individual cases. are working, then the dose of chemotherapy will need to change or stop.

    Studies Cancer, & & Stories CBD Oil Success Cannabis for Dosage,

    We have two different types of cannabinoid receptor, CB1 and CB2, which are found in different locations and do different things. CB1 is mostly found on cells in the nervous system, including certain areas of the brain and the ends of nerves throughout the body, while CB2 receptors are mostly found in cells from the immune system.

    Over the past couple of decades scientists have found that endocannabinoids and cannabinoid receptors are involved in a vast array of functions in our bodies, including helping to control brain and nerve activity including memory and pain , energy metabolism, heart function, the immune system and even reproduction.

    There is no doubt that cannabinoids — both natural and synthetic — are interesting biological molecules. Virtually all the scientific research investigating whether cannabinoids can treat cancer has been done using cancer cells grown in the lab or animal models.

    All these effects are thought to be caused by cannabinoids locking onto the CB1 and CB2 cannabinoid receptors. All the patients died within a year, as might be expected for people with cancer this advanced. A handful of other clinical trials of cannabinoids are currently being set up. There are still a lot of unanswered questions around the potential for using cannabinoids to treat cancer.

    An antique bottle of cannabis extract. So far there have been intriguing results from lab experiments with prostate, breast, lung cancer, skin, bone and pancreatic cancers, glioma brain tumours and lymphoma. Most research has been focused on THC, which occurs naturally in cannabis plants, but researchers have found that different cannabinoids seem to work better or worse different types of cancer cells.

    Lab experiments have shown promising results with THC on brain tumour and prostate cancer cells, while CBD seems to work well on breast cancer cells. This makes it hard to get them deep into a tumour, or even just deliver them into the bloodstream in consistently high enough doses to have an effect.

    There are hundreds of exciting potential cancer drugs being developed and tested in university, charity and industry labs all over the world — cannabinoids are merely a small part of a much larger picture. Most of these compounds will never make it into the clinic to treat patients for a huge range of reasons including toxicity, lack of effectiveness, unacceptable side effects, or difficulty of delivering the drug to tumours.

    If cannabinoids are ever to get into clinical use, they need to overcome these hurdles and prove they have benefits over existing cancer treatments. But can they stop the disease from developing? Or could they play a role in causing cancer? In experiments with mice, animals given very high doses of purified THC seemed to have a lower risk of developing cancer, and there has been some research suggesting that endocannabinoids cannabinoids produced by the body can suppress tumour growth.

    This is mainly because most people who use cannabis smoke it mixed with tobacco, a substance that definitely does cause cancer. In some parts of the world — including the Netherlands — medical use of marijuana has been legalised for palliative use relieving pain and symptoms , including cancer pain.

    But one of the problems of using herbal cannabis is about dosage — smoking it or taking it in the form of tea often provides a variable dose, which may make it difficult for patients to monitor their intake. So researchers are turning to alternative dosing methods, such as mouth sprays, which deliver a reliable and regulated dose.

    We want to see safe, reliable and effective treatments become available for patients as quickly as possible. We receive no government funding for our research, and it is all paid for by the generosity of the public. This is obviously not a bottomless purse, and we do not have financial reserves to draw on. Because of this limitation, we can only fund the very best research proposals that come to us that will bring benefits to people with cancer. Our funding committees have previously received other applications from researchers who want to investigate cannabinoids that have failed to reach our high standards for funding.

    If we receive future proposals that do meet these stringent requirements, then there is no reason why they would not be funded — assuming we have the money available to do so. But whole plants or other organisms are a complex mix of hundreds of chemicals not all of which may be beneficial and contains low or variable levels of active ingredients.

    This makes it difficult to give accurate doses and runs the risk of toxic side effects. Foxgloves — a source of medically useful chemicals. These drugs are now used to treat many thousands of people around the world with heart failure and other cardiac problems. But the entire plant itself is highly toxic, and eating just a small amount can kill.

    But this naturally-occurring chemical causes severe stomach irritation, which led to the German company Bayer developing an alternative version — acetylsalicylic acid — which was kinder to the tummy.

    Aspirin is now arguably one of the most successful drugs of all time, and is still being investigated for its potential in preventing or even treating cancer. As we said above, there is no good evidence that natural cannabinoids, at the doses present in simple cannabis preparations, can treat cancer in patients.

    There is a strong and persistent presence on the internet arguing that cannabis can cure cancer. Despite what the supporters of these sources may claim, videos and stories are not scientific evidence for the effectiveness of any cancer treatment. It is hypothesized that the cannabis was used to manage her pain and perhaps other symptoms, or even possibly as a treatment for her malignant disease.

    Widely used as medicine during the ensuing millennia, cannabis disappeared from the pharmaceutical armamentarium in the s as its prohibition took hold. Today, we are in the midst of what appears to be something of a medicinal cannabis renaissance, with patients across the globe gaining increased access to this potent botanical medicine. Regrettably, most oncologists trained during the era of cannabis prohibition and have no knowledge of how to use the plant as medicine.

    In these days of targeted therapies and nanotechnology, the modern oncologist might feel somewhat ill at ease recommending a herbal intervention, notwithstanding the number of potent cytotoxic chemotherapeutic agents derived from plants. An even more vexing concern to the oncologist is the lack of data on which to base treatment recommendations.

    Given the nature of the drugs that they prescribe, oncologists are used to seeing strong evidence of a favourable risk—benefit ratio before recommending a therapeutic intervention.

    Usually, oncology drugs have proceeded through preclinical studies, followed by the traditional phase i , ii , and iii analyses, before we feel comfortable adding them to our toolbox. Such data about the clinical effectiveness of medicinal cannabis are all but lacking. In the United States, cannabis is classified as a Schedule I agent with a high potential for abuse and no accepted medical use.

    The study of cannabis requires a special Schedule I license from the U. In addition, the only legal source of cannabis for clinical trials is the National Institute on Drug Abuse, which has a congressional mandate to study substances of abuse only as substances of abuse. Although investigators can obtain National Institute on Drug Abuse cannabis to conduct effectiveness clinical trials, funding must come from another source.

    Hence, carefully controlled clinical trials of cannabis as a therapeutic agent—the sorts of trials that would satisfy a data-driven oncologist—are quite rare.

    Hence, oncologists probably have the longest record of using a cannabis-based medicine. In , the dronabinol indication was expanded to include treatment of the anorexia associated with aids wasting syndrome. In , nabilone Cesamet: The foregoing drugs are thc alone and do not include any of the other potentially therapeutic cannabinoids, terpenoids, or flavonoids that are present in the whole plant 3.

    Cannabidiol cbd , in particular, is another of the phytocannabinoids that has been generating significant interest for its potential therapeutic effects 4. GW Pharmaceuticals, Salisbury, U. Originally approved in Europe for the treatment of central pain associated with multiple sclerosis, this sublingual preparation has also been studied in a number of cancer-related conditions 5 — 8.

    Because most of the information derived from clinical trials on cannabinoids in cancer is derived from studies of those licensed pharmaceuticals, the present review discusses findings from studies of those agents as well as from studies of cannabis itself.

    To date, two types of cannabinoid receptors seven-transmembrane domain G protein—coupled receptors have been identified in humans and other animal species 9. The cb1 receptor, initially identified in the brain, is found in high concentrations in areas involved in the processing of noxious stimuli. The cb2 receptor is predominantly located in cells of the immune system and likely has a role in the control of inflammation and cell proliferation. The cb receptors are not present to react with the phytocannabinoids from cannabis alone.

    It has been suggested that the entire function of the system of cannabinoid receptors and endocannabinoids might be to assist in modulation of the response to pain. With that in mind, it is not surprising that an increasing body of knowledge is being developed about the effects on pain of cannabinoid medicines.

    A recently published systematic review 10 considered 28 studies involving a total of participants and preparations including inhaled cannabis, dronabinol, nabilone, and nabiximols, among others. Twelve of the studies investigated neuropathic pain, and three looked at patients with cancer pain. The studies generally showed improvement in pain measures, with an overall odds ratio of 1.

    An earlier systematic review of eighteen randomized controlled trials of cannabinoids in participants with chronic non-cancer pain found that fifteen of the studies reported a significant analgesic effect for the cannabinoids compared with placebo, and a number of the studies also noted improvements in sleep Another review that included six of those eighteen studies in patients with cancer-related pain also favoured cannabinoids Neuropathic pain is certainly problematic in cancer patients A systematic review of six randomized, double-blind, placebo-controlled trials of cannabinoids five specifically addressing neuropathic pain found evidence for the use of low-dose medical cannabis in refractory neuropathic pain in conjunction with traditional analgesics Another analysis reviewed five trials of inhaled cannabis in patients with hiv -related peripheral neuropathy and again found a positive effect for cannabis compared with placebo A recent small study 16 showed a dose—response effect for vaporized cannabis in the relief of pain from diabetic peripheral neuropathy, a huge clinical problem estimated to affect million people worldwide.

    With all of those impressive data suggesting that cannabinoids could be effective in peripheral neuropathy, where are the studies in patients with chemotherapy-induced peripheral neuropathy?

    Preclinical studies in rodent models have suggested that cannabinoids might actually be able to prevent peripheral neuropathy. Activation of the cb1 and cb2 receptors suppresses the development of vincristine-induced peripheral neuropathy in rats In mice receiving daily cisplatin, administration of anandamide an endocannabinoid together with an inhibitor of the fatty-acid amide hydrolase that metabolizes anandamide attenuated chemotherapy-induced peripheral neuropathy Cannabidiol pretreatment stops paclitaxel-induced neuropathy in mice To date, the only human study of a cannabis-based medicine in chemotherapy-induced peripheral neuropathy is a crossover placebo-controlled trial of nabiximols Overall, reported pain scores were not different with nabiximols and with placebo.

    However, on a 0—10 scale, 5 responders reported a greater than 2-point decline in neuropathic pain. That observation suggests that 5 patients have to be treated with the sublingual preparation for 1 to experience clinical benefit an acceptable number-needed-to-treat for a neuropathic condition , suggesting that further investigation of cannabis medicines in chemotherapy-induced peripheral neuropathy is warranted.

    Even more exciting would be a study demonstrating the potential for cannabis to actually lower the risk for neuropathy or to prevent it from developing in the first place, as the animal models suggest. In animal models, cannabinoids and opioids have been demonstrated to have synergistic analgesic effects Analgesic effects of cannabinoids are not blocked by opioid antagonists, suggesting that the two types of agents work through different receptors and pathways.

    An early study found that thc was ineffective as an analgesic on its own, but that it slightly increased the effect of morphine on 2 of 3 measures A randomized controlled trial of nabiximols in cancer patients with poorly controlled pain despite a stable opioid regimen found that the sublingual preparation 4, 10, or 16 sprays daily for 5 weeks reduced both pain and sleep disruption A pharmacokinetic interaction study of vaporized cannabis in 21 patients with chronic—mostly non-cancer—pain taking sustained-release morphine or sustained-release oxycodone showed no significant effect on plasma levels of the opiates, but a suggestion of enhanced analgesia However, that small study was not powered for a pain endpoint, suggesting that a larger follow-on trial is warranted Clinically, I have observed that many cancer patients benefit from adding cannabis to their pain regimen.

    Although the effect on chemotherapy-induced peripheral neuropathy has not been glaringly obvious, other sorts of cancer-related pain appear to respond.

    Patients who have been put on high doses of opiates at the end of life by their well-meaning oncologist or palliative care team frequently feel totally unable to communicate with their loved ones in their precious remaining time because of altered cognition. Many have successfully weaned themselves down or off their opiate dose by adding cannabis to their regimen.

    Although it would seem that thc -dominant strains of cannabis would be most likely to have analgesic effects, patients often report significant pain reduction from strains that are predominantly cbd -rich. Although cbd does not actually bind to the cb1 receptor, it does block the fatty-acid binding protein that transports the endocannabinoid intracellularly to be hydrolyzed by the fatty-acid amide hydrolase, hence allowing the endogenous cannabinoid complexed with the receptors to persist As an oncologist practicing medicine in San Francisco since the early s, I have often said that I need a clinical trial to demonstrate that cannabis is an effective antiemetic about as much as I need a placebo-controlled trial to demonstrate that penicillin is an antibiotic!

    It would appear that, if the single most active constituent of the plant is licensed and approved for treatment of chemotherapy-induced nausea, that the parent botanical should also work. Being aware that the plural of anecdote is not evidence, I would like to share an e-mail message from a year-old gentleman with metastatic colon cancer requesting a renewal of his medical cannabis authorization:.

    Although I did not use it until my last 5 sessions of chemo me getting over the stigma of its use , it did what no other drug could do, completely solve the severe nausea I had.

    It allowed me to play with my children, attend their sports and school functions, and just function very normally in day to day activities. I am currently on a chemo vacation after a clean scan, and the only time I use medical marijuana now is when I have trouble sleeping.

    I would like to continue to use it for that purpose instead of relying on pharmaceutical options like zolpidem etc. That message is representative of what many patients have recounted to me over the past plus years of oncology practice in a locale in which patients have never had difficulty accessing cannabis.

    However, data from controlled clinical trials of cannabis are less impressive. Only three trials have looked at cannabis in the treatment of chemotherapy-induced nausea and vomiting, and in two of them, cannabis was made available only after dronabinol had already failed. The first trial noted a significant benefit for cannabis compared with placebo in patients receiving high-dose methotrexate A later study by the same investigators made cannabis available to patients receiving cyclophosphamide or doxorubicin after dronabinol failure, and no beneficial effect was noted The third study investigating cannabis was a randomized crossover trial in 20 patients who received dronabinol and cannabis Overall, 5 of the patients reported a positive antiemetic response.

    Of the entire cohort, 4 patients preferred smoked cannabis, 7 preferred dronabinol, and 9 had no preference. A recent phase ii investigation in 16 patients of nabiximols, the sublingually delivered whole-plant extract, found that 4. A quantitative systematic review 32 that included 30 randomized comparisons of oral nabilone, oral dronabinol, or the intramuscular levonantradol preparation no longer available with placebo in patients receiving chemotherapy found that, as antiemetics, cannabinoids were more effective than prochlorperazine, metoclopramide, chlorpromazine, thiethylperazine, haloperidol, domperidone, or alizapride risk ratio: For complete control of nausea, the number needed to treat was 6, and it was 8 for complete control of vomiting.

    In crossover trials, the patients preferred cannabinoids for future chemotherapy cycles. A later systematic review 33 of thirty randomized controlled trials involving patients also found that cannabinoids were more effective than placebo or conventional antiemetics in reducing chemotherapy-induced nausea and vomiting, and that patients preferred the cannabinoids.

    Adverse effects were noted to be more intense and to occur more frequently in patients using cannabinoids. A more recent systematic review 10 of twenty-eight randomized controlled trials twenty-three using nabilone or dronabinol involving participants reported an overall benefit for cannabis. A Cochrane review 34 analyzed twenty-three randomized controlled trials of cannabinoids compared with placebo or with other antiemetic drugs. Patients were more likely to report a complete absence of nausea and vomiting with cannabis than with placebo, and there was little discernable difference between the effectiveness of cannabinoids and of prochlorperazine, metoclopramide, domperidone, and chlorpromazine.

    Notably, however, none of the trials involved the agents now most widely used—the serotonin 5-HT 3 antagonists. The National Comprehensive Cancer Network guidelines cautiously mention cannabinoids as a breakthrough treatment for chemotherapy-induced nausea and vomiting not responsive to other antiemetics Although cannabis is the only antiemetic that is also orexigenic, no clinical trials investigating the plant as a treatment for cancer-related anorexia—cachexia syndrome have been conducted to date.

    A randomized placebo-controlled clinical trial evaluating a cannabis extract and dronabinol in patients with cancer-related anorexia—cachexia syndrome found that neither preparation was superior to placebo with respect to affecting appetite or quality of life A large study of advanced cancer patients randomized participants to receive the progestational agent megestrol acetate or dronabinol, or both Compared with participants in the dronabinol group, those in the megestrol arm experienced a significantly greater increase in both weight and appetite, and combining dronabinol with megestrol offered no additional benefit compared with megestrol alone.

    One smaller study of dronabinol in cancer patients demonstrated enhanced chemosensory perception in the treatment group compared with the placebo group In the dronabinol recipients, food tasted better, and appetite and caloric intake increased. Similarly variable and largely unimpressive results for dronabinol with respect to appetite and weight in hiv -associated wasting have also been reported One of the lay accounts concerning the tomb of the Siberian Ice Maiden closes with these lines:.

    Modern-day scientists have increasingly been turning their attention to cannabis due to its potential to inhibit or destroy cancer cells, and at the very least, manage the pain and symptoms that come with the illness.

    But then, ancient people seem to have known that already. That sort of a leap—assuming that because the Ice Maiden was buried with cannabis and had cancer, that she was using it to treat her cancer—is about as valid as the claims being made on the Internet today that highly concentrated cannabis oils can cure cancer.

    It might be possible, but there is, as yet, no solid evidence to support that belief. One of the more distressing situations that oncologists increasingly face is trying to counsel the patient who has a curable diagnosis, but who seeks to forego conventional cancer treatment in favour of depending on cannabis oil to eradicate their malignancy because of the large number of online testimonials from people claiming such results.

    Given my long practice in San Francisco, I can assume that a large proportion of my patients have used cannabis during their journey. If cannabis cured cancer, I would have a lot more survivors in my practice today. Granted, inhaled cannabis cannot deliver the concentration of active ingredients that a heavily concentrated thc or cbd oil can, but there is as yet no convincing demonstration that the in vitro or animal model findings translate into the clinical arena.

    One of the earliest studies suggesting that cannabinoids might have anticancer activity came from the U. National Cancer Institute in a paper published in For unclear reasons, that line of research was not pursued further at the National Institutes of Health in the United States, but was subsequently picked up by investigators in Spain and Italy, who have made enormous contributions to the field.

    If cannabinoids are postulated to have a potential anticancer effect working through the cb1 receptor, it would follow that the brain—where the cb1 receptor is the most densely populated seven-transmembrane domain G protein—coupled receptor—would be a good place to start the investigation.

    And, in fact, numerous studies in vitro and in animal models have suggested that cannabinoids can inhibit gliomas Other tumour cell lines are also inhibited by cannabinoids in vitro, and cannabinoid administration to nude mice curbs the growth of various tumour xenografts representing multiple solid and hematologic malignancies, including adenocarcinomas of the lung, breast, colon, and pancreas, and also myeloma, lymphoma, and melanoma 43 ,

    Cannabis health products are everywhere – but do they live up to the hype?

    Studies And Clinical Trials a) Alzheimer's Disease. 7 b) Cancer. 9 c) Chronic Pain. 11 Side effects and risks of medicinal cannabis are very well documented in the literature, much of which is focused . Cancer. The anti cancer properties of THC, CBD, CBG and other cannabinoids are well .. Cannabis Oil Testimonials. No other forms of treatment were used while taking the oil. Does this list prove that cannabis oil cures cancer? The ECS was discovered by scientists studying how cannabis interacts with the brain. Anecdotal and lab evidence shows that using a higher ratio of CBD to THC oil is best in these cases. Rick Simpson oil is a type of cannabis oil that contains high levels of results suggest that THC and CBD may help to prepare cancer cells to However, these side effects may only last for a few hours and related stories.

    What is cannabis?



    Comments

    misa222

    Studies And Clinical Trials a) Alzheimer's Disease. 7 b) Cancer. 9 c) Chronic Pain. 11 Side effects and risks of medicinal cannabis are very well documented in the literature, much of which is focused . Cancer. The anti cancer properties of THC, CBD, CBG and other cannabinoids are well .. Cannabis Oil Testimonials.

    mirry

    No other forms of treatment were used while taking the oil. Does this list prove that cannabis oil cures cancer? The ECS was discovered by scientists studying how cannabis interacts with the brain. Anecdotal and lab evidence shows that using a higher ratio of CBD to THC oil is best in these cases.

    aktebronak

    Rick Simpson oil is a type of cannabis oil that contains high levels of results suggest that THC and CBD may help to prepare cancer cells to However, these side effects may only last for a few hours and related stories.

    MangoStas

    You can read the original article here and donate to Cancer Research UK here. . cannabidiol (CBD), a cannabinoid found in cannabis plants that counteracts was treated with cannabis extracts (also referred to as “hemp oil”), but there . diagnosis, treatment, leading to a doubling in survival rates over the past 40 years.

    saeha

    Cannabis oil can contain varying amounts of CBD and THC. If you are thinking There are side effects of using cannabis oil. THC can But these are individual stories and not based on clinical research trials. If you are.

    Hidrus

    Simpson had had success in treating other ailments in the past, and decided to for Cancer Research showed that THC and CBD were helpful when used the effectiveness of the radiation treatment due to the THC and CBD may The girl used RSO and hemp oil regularly, which appeared to help treat.

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