Need some scientific research before you buy CBD oil? We have some great facts about CBD oil, uses, and why you should put it to use today. The Science Behind CBD Oil: Everything You Need to Know But you may not be aware that marijuana's close cousin, hemp, is also a hot topic. .. so it's important to know what to look for when buying or using a product. What does science have to say about the extract's proposed health Depending on whom you ask, CBD oil can relieve pain, aid sleep, inspire.
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As an educator, to understand more how cannabis effects the brain in adolescents makes it…. God, Cannabis, and Lots of Conflicting Information. TerpenesAndTesting Editor Sep 24, CBD is one of active compounds found in cannabis and is especially abundant in hemp which is a subspecies of cannabis , however it can also be found in other types of cannabis in significant amounts.
This post is over 4, words long—hence I made a PDF version of it so you can read it at your own convenience. Just let me know where to send it takes 5 seconds. Send me the PDF. CBD produces healing effects through several biochemical pathways and research studies found that it relieves anxiety, psychosis, nausea and inflammation , among many other things. For instance, CBD is more effective than vitamin C and E as a neuroprotective antioxidant and can ameliorate skin conditions such as acne.
CBD interacts with the endocannabinoid system and the endocannabinoid system is implicated in pretty much all diseases. So theoretically, if one modulates the endocannabinoid system as CBD does, you could be affecting many many different conditions.
Now, anandamide is a neurotransmitter that binds to CB1 and CB2 receptors part of our endocannabinoid system and boosting its levels produces a bunch of positive effects on the body — regulates pain perception by desensitizing TRPV1 receptors , increases appetite, kills cancer cells, increases neurogenesis therefore lowering anxiety and depression and modulates the immune system response.
Secondary effects of CBD come from its activation of 5-HT1A receptors and several ion channels that stimulate production of serotonin, mediate pain perception, inflammation and body temperature. CBD also stimulates the production of endorphin which also makes you feel awesome and oxytocin, a hormone that produces anti-aggressive and calming effects and is responsible for the feeling of emotional bonding.
CBD blocks GPR55 receptor signaling, with preliminary research showing a possible effect in slowing down the growth of certain cancers. Very preliminary in vitro and animal studies have shown that inhibiting GPR55 signaling reduces tumor growth. This time is, of course, subjective, and requires experimentation with different dosages at different times of the day.
CBD edibles can take effect in anything between hours and topicals usually take minutes. Take note that there is no standard here and that almost everything related to cannabis dosing is highly subjective.
Studies done on humans focused on using oral administration or inhalation so they correlate pretty well in their reported results with how the general public would use CBD. Back in , Bergamaschi created a review of CBD studies, analyzing both effects and side effects of this amazing compound.
The side-effects of CBD have mostly been found in vitro or in animals studies. Human studies did not show any side effects. In vitro and animal studies found a few issues with CBD, revolving around alterations of cell viability, reduced fertilization capacity, and inhibition of hepatic drug metabolism and drug transporters. Other reported side effects of CBD are mild to low and include low blood pressure, dry mouth, light-headedness, sedation and drowsiness.
Studies say that mixing CBD with pharmaceuticals might produce some side effects, as CBD interacts with drug metabolizing enzymes that belong to the cytochrome P family. For folks out there that are not chemistry majors, this means that CBD is metabolized via an enzyme that various drugs inhibit. In the end, most studies recommend consulting your physician before mixing CBD with pharmaceutical drugs.
CBD does interact with a lot of different pharmaceuticals and if one is taking particularly high doses of CBD as an isolate single molecule CBD which is sold on the Internet under the false assumption that CBD alone is better than CBD with the other components of the plant you run into a problem with drug interactions. The trick to getting the CBD dosage right is to start with a low minimum dose and gradually increase the dosage until you feel better. Only then should you keep it at that level for up to 90 days or longer.
For people who suffer from medium to high severity of symptoms, this starting dosage can go up to mg of CBD a day. However, there is a big obstacle in CBD dosing and that is the fact that patients cannot figure out how to calculate their CBD dosage and how many drops to take. When you buy a CBD product, for example oil, its producer should provide information on how much CBD is in every milliliter gram.
Our fictional oil provides 1. Remember, you need 12 mg of CBD per day at first, so drops of this particular fictional oil per day will help you meet your daily dose. As I previously mentioned, it takes up to 2 hours for CBD to kick in, so after each application wait a bit and see how you respond. This not only mildly activates the receptors, but is also thought to trigger the body to create more CB 1 and CB 2 receptors, a process known as upregulation.
It also results in increased natural levels of anandamide. When the body experiences an increase in CB receptors, it becomes more sensitive to the natural endocannabinoids anandamide and others already present in the body. CBD also modulates other receptors in the body. For instance, modulation of the 5-HT1A receptor involved with serotonin, a mood hormone provides mood-balancing properties: Another example is modulation of opioid receptors, which provides pain relief and tissue-supporting properties.
Cannabis plants also possess a wide spectrum of different chemical components offering a range of medicinal properties. Aside from cannabinoids, one of the most prominent chemicals in cannabis plants is terpenes, organic and aromatic compounds found in essential oils. Terpenes are beneficial on their own. For instance, research in the British Journal of Pharmacology found that terpenes are gastro-protective, suggesting they may be beneficial to people with ulcers, and that they have anti-inflammatory properties.
It also points to the importance of using a full-spectrum extract of hemp, which provides a full range of chemical components including terpenes, as opposed to purified CBD or CBD isolate, which contains only CBD. Cannabinoids, including cannabidiol CBD , work by mimicking natural endocannabinoids like anandamide described above in the body.
Endocannabinoids are part of a complex messaging system in the body called the endocannabinoid system. The endocannabinoid system oversees or regulates parts of the nervous system, endorphins, immune system functions, hormones, mood and emotions, metabolism, and many other chemical messengers in the body.
Like other cannabinoids, CBD readily crosses the blood brain barrier, making it ideal for affecting central nervous system conditions. CBD helps calm the nervous system, reduces inflammation, and is strongly neuroprotective.
Not surprisingly, clinical studies evaluating cannabidiol for treatment of anxiety , post traumatic stress disorder PTSD , seizure disorders especially childhood seizures , and even schizophrenia have shown remarkable effectiveness. Management of chronic pain is another application for which CBD is ideally suited, and it works in a number of ways.
It and other non-THC cannabinoids found in hemp flower-bud extracts work to block pain-conducting nerve impulses, which reduces your perception of pain.
Stimulation of CB 1 in the brain increases dopamine , which counteracts pain. Just as importantly, these same chemical substances reduce inflammation , the driving force behind pain , which allows healing to occur.
CBD and other cannabinoids also reduce pain by affecting endorphins, the feel-good chemicals we naturally produce to suppress pain. Unlike opioids heroin, narcotics , which mimic endorphins and ultimately suppress natural endorphins, cannabinoids modulate endorphins. This means, in effect, that CBD and cannabinoids increase natural endorphins. So instead of causing dependence and addiction like opioids, CBD and cannabinoids do the opposite — so much so that CBD has proven valuable for countering narcotic and cocaine addiction.
From a medicinal standpoint, the fact that CBD has the potential to relieve pain without causing euphoria, intoxication, or addiction makes it an intriguing therapeutic option — it has high potential for being at least a partial solution to the current opioid epidemic.
CBD and other chemical substances in hemp flower-bud extracts are strong immune system modulators. This means they control inflammation throughout the body, and also fine-tune the immune system for optimal performance. The wide range of benefits associated with cannabis have garnered interest for use in cancer therapy. Research suggests that cannabinoids, including CBD, may have anti-tumor effects.
While this is not enough to define cannabis as a treatment for cancer, it does make it attractive as a complement to other therapies , for both reducing symptoms and possibly enhancing the effects of anticancer drugs.
Terpenes and the wide spectrum of other chemical compounds found in hemp flower-bud extracts provide potent anti-inflammatory and antioxidant properties. This is a common source of confusion. Many people see hemp oil on grocery store shelves and assume or wonder if it contains CBD and other cannabinoids. The hemp oil you might see on grocery store shelves is made by cold pressing hemp seeds.
While hemp oil is a healthful option for a salad dressing, it has no medicinal value by itself. Cannabinoids, including CBD in hemp and THC in marijuana, are most highly concentrated in the flower buds, not the seeds. These chemical components of the plant must be extracted from the flower buds to be useful.
For medicinal use, cannabinoids are extracted from hemp and concentrated into a thick oil that, when ingested, elevates blood levels of cannabinoids for a more sustained period of time. CBD oil from hemp contains CBD and other cannabinoids, along with terpenes and other chemical components. The most common method, chemical extraction uses alcohol or hexane as solvents.
The solvent is dried off, leaving the dense oil — and possibly harmful residual solvents — behind. A newer method, CO 2 extraction is done without using chemical solvents. Instead, it uses carbon dioxide to extract the full range of chemical components from the flower buds and then distill them into dense CBD oil. Also sometimes called thermal extraction, vapor distillation uses hot air to safely vaporize the full spectrum of chemical components at high concentration from the buds, and then the vapor is distilled into CBD oil.
This method also activates the cannabinoids by removing an extra carboxyl ring from their molecular chain a chemical reaction called decarboxylation , enabling them to interact directly with CB receptors for maximal medicinal value. I believe vapor distillation is the best method for obtaining the full range of activated chemical compounds from the cannabis plant.
This method preserves the terpenes, which are beneficial on their own, and also enhance the properties of CBD via the entourage effect.
The upsides of lipid-based extraction are that the fat helps make the CBD more bioavailable easy to absorb , and there are no harsh solvents used. Condensed CBD oil can be taken as a thick paste, but this is the least pleasant option. More commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, to a specific concentration of CBD.
The distinctive taste — which comes from the terpenes and not the cannabinoids — is often masked with chocolate, mint, or other flavorings. It typically comes in a small bottle with a dropper to administer the oil mixture. The best way to take CBD oil mixed with a carrier oil to a specific concentration is to place a few drops or dropperfuls under your tongue for 15 seconds to access the sublingual gland. There, the CBD is absorbed directly into the bloodstream called sublingual consumption or administration for the fastest acting effects.
Another method is to take a few drops or dropperfuls orally, swish the liquid around in your mouth, and then swallow it.
CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract.
The average dose range is mg of CBD, one to three times per day, though much higher doses of mg sometimes required to control pain are equally well tolerated. Some people will notice benefit at the lower end of the dose range, but most people will need mg to notice any effects.
Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.
A dropperful of the medium grade product mg of CBD per fluid ounce will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product mg CBD per fluid ounce will provide about 50 mg of CBD per dropperful.
CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience the benefits.
As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance. Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use.
CBD isolate which is CBD alone acts very differently in the body than a spectrum of hemp chemical components. Here are some quick definitions:.
The Science Behind CBD Oil: Everything You Need to Know
Everything you need to know about CBD oil Authors of a study published in the Journal of Experimental Medicine found that CBD significantly . There is a selection of CBD products available for purchase online. . Retrieved from https ://writingdesk.pw Discover the top then CBD facts you need to know to make informed decisions found in cannabis, and as such have undergone the heaviest scientific study. One example of an endocannabinoid is anandamide, or 'the bliss molecule. Billy had flown with his mother to Canada to buy the CBD oil – which helps to Cannabis sativa L, the scientific name of the cannabis plant.