CBD for Alzheimer's Disease Treatment: A Very Intriguing – and Very Real – Possibility. In fact, according to ProjectCBD, over two dozen. Article (PDF Available) in Journal of Alzheimer's disease: JAD 42(4) · July with 7, Reads . ability, increased motor agitation, and likelihood of evaluated for the very ﬁrst time the effectiveness of CBD has also been shown to be effective in vivo making the phytocannabinoid an interesting candidate for novel. Episode CBD Oil and Alzheimer's Disease In this episode, Dr. Daniel This is very true. In , you became Vice President for Disease Management at AWAC, People are definitely very curious about the effects of this versus The other interesting thing is, is that we know that cannabidiol oil.
Intriguing – Very Possibility Disease Treatment: Real – Alzheimer’s for and A CBD Very
In an older study from , CBD was shown to have a neuroprotective effect on cells. Research has shown that exposure to a protein called beta-amyloid causes brain cells to become toxic and die. This was shown to be caused by oxidation, increased enzyme destruction, DNA fragmentation and increased cellular calcium.
In this study, they pretreated cells with CBD and then exposed them to beta-amyloid. The results showed that cellular survival was drastically increased, and it was due to reversal or prevention of the same damage noted without pretreatment. It must be kept in mind that this study was on rat brain cells in culture dishes, not in rats or humans. So, there is a leap to live human brains. In , a study showed that when live mice were injected with a brain damaging peptide like study above, but with live mice brains and then treated with CBD damage was significantly less than those injected with just a placebo.
However, the data set is small, and it is suggested that many more larger studies are needed to make these specific claims. It did suggest that treatment for epilepsy is supported and that clinical studies supporting various products about to come on the market were justified. In a second article from , pretreatment of mesenchymal cells with CBD offered protection against damage. It is interesting to note that this study is suggesting that proteins are changed at the level of RNA transcription via downregulation in the presence of CBD.
This is saying that having CBD present impacts the cellular mechanisms to protect the cells from damage that would otherwise occur.
This is an interesting study in that it occurred in live animals with fully intact brains. One of the more recent articles has drawn an interesting conclusion related to THC. As you recall, this is the active material in marijuana that causes a person to get high.
This study showed that THC not only inhibited the enzyme that is related to the build up of beta amyloid proteins, but also kept them from aggregating. This means that the build up of the damaging protein is considerably lessened. This is a very new concept that is actively being pursued. I have tried several preventative medications over the years lyrica, topomax, Elavil, botox, Effexor, occipital nerve block injections etc , with fleeting success.
I also suffer from chronic neck tension and pain resulting from disc bulges caused by a previous accident which exacerbates the headaches. I live in Florida and have been told that I automatically qualify for a medical marijuana card as I am a breast cancer survivor 3 years in remission.
I work full-time, have 2 small children, and am pursuing my MBA. I need to be fully functioning. I am MOST concerned about any contraindications that it might have on Tamoxifen that I have been prescribed to take for 7 more years. Not sure that I can handle the anxiety of wondering, what if…. He is 55 years old. There is a huge amount of anecdotal evidence that it helps people, certainly with their symptoms, but it really needs to be studied more rigorously.
I took my life in my own hands cold turkey off 20 years of pills. Maybe not the smartest thing to do however with weed I did it. Not cured but I can manage my life with weed and probiotics. I have my brain back.
My pain is way down. Weed is life changing and healing and hopeful!! Glad that you found relief from your symptoms. Certainly, you are not alone, which is why doctors and patients need to become better educated on this topic, and more research needs to be done!
There are many different ways to consume medical marijuana: Actually, several studies have compared the lungs of a marijuana smoker to those of a tobacco user, and the marijuana smokers have had a much higher lung capacity. Some studies have also showed that repetitive marijuana use can eventually slow the effects of tobacco.
THC in marijuana has been proven to bind to the brain cells that relate to, and control excitability and relaxation. All Cannabis should be grown organically, never have the males removed and the object is to gain as many of the cannabinoids as possible to bring about whole health.
How the oils and tinctures are made are very important and given the USA is getting it completely wrong and are now years behind what we in the Cannabis compassion suppliers are finding and now know. There is absolutely no health or safety risk using Cannabis from conception to the grave. Anyone and everyone should be able to grow the plant and use it as they please as you should any other herb or vegetable, it should not be on a drugs list and it should not be under the control of drug companies or the medical profession.
My father is Dr. If THC is removed, is there pain relief? In other words — is there pain relief and PTSD help etc. CBD, another cannabinoid, does have pain controlling effects as well, without the psychoactive effects. Thanks for the interesting article. It is a very emotive subject. As I see as Governments etc can make money from medical marijuana then they will take it on board. It is a nonsense that the large pharma countries are legally killing people and it is only recently that many of us are waking up to natural medicine.
Take the large alcohol manufacturers, lover the world over by Governments and their paymasters as it generates so much revenue for them. This is despite the devastation that this drug causes to some many families the world over. Tell me please, is there any statistics on how the number of traffic accidents has changed after some states of the USA have allowed the use of marijuana?
It would be interesting to know statistics on cars and motorcycles. This study from NIH National Institute of Health shows impairment but not as dangerous as alcohol which is a good summary of marijuana in general… https: There are studies on this exact topic! This is a recent article looking at two studies. I find more weight in the study conducted by AJPH, in part because it is more extensive.
Of course driving impaired is not to be condoned and this is a topic worth researching. Information on drugs interaction are rare. Do you know the intersections with new oral anticoagulants such as Apixaban?
One of my patient with ALS got a recurrent pulmonary embolism on treatment with apixaban and oil cannabis. The case you cite could just be treatment failure and have nothing to do with the cannabis…. Two anticoagulants would cancel each other out, so to speak? Cannabis oil extraction is advancing quite dramatically as well.
The healing properties of these oils can even be recombined to specifically treat different types of ailments. What is needed, is more information to identify which compound from the plant that is aiding their specific ailment.
Genetic profiles of strains are even being mapped to aid researchers in identifying which may best be helpful to patients in the future. Of course, it is expanding every day because of articles like this and doctors like you, but I digress. The archaic views putting marijuana in the Schedule 1 rating along with heroin, methamphetamines, etc. I reference the life experience of Canadian entertainer Alan Park Royal Canadian Air Farce sketch comedy ensemble, popular national Canadian comedy television show.
He used RSO in a suppository form and purportedly reduced his psa blood test from around to close to zero, over maybe a five month period! He was diagnosed at stage four prostate cancer after going to the Doctor for an unrelated complaint, and subsequent diagnostic tests revealed his totally unsuspected, and late stage, prostate cancer.
He apparently could not be offered any conventional treatment per the assessment of his Physician due to the advanced stage of his prostate cancer condition. The Doctor gave him about three months to live. He has celebrated three years of survival since that initial cancer diagnosis. Rick Simpson is a Canadian citizen that apparently has been under legal duress associated with his total marijuana plant conversion to oil concentrate of some sort. Alan Park uses the RSO in suppository form.
If his health story journey is accurate, and positively in support of prostate cancer treatment in a genuinely efficacious and measurably evidenced based way, we should get our interest directed in this area of inquiry, most ricky ticky!
It certainly sounds compelling to me, at least on the face of his narrative of his very unconventional personal experience and testimony. Doctors are the leading cause of Opioid addiction in America. They continue to prescribe Oxycontin like it was candy and then after the prescription runs out, their patients turn to the only available alternative; Afghanistan grown US Military protected Heroin.
The greatest threat to American youth is the ignorance and arrogance of the AMA and a Federal Government that refuses to consider Marijuana as an adjuvant for pain mitigation.
Shame on us for tolerating a corrupt alcohol-based establishment and perpetuating the Nazi-era marijuana prohibition laws.
So are millions of others of people. Pills kill, cannabis heals. They need to convince and educate themselves. They need to remember the Hippocratic oath to first do no harm, and death pills are killing people every 15 minutes in America.
Stop with the pills already!!!!!! Here you describe Marijuana legalization, use regarding health and Pain control but they should take it after getting a recommendation from MMJ doctor, Which is very necessary.
Health effects of recreational and medical use Patient-Centered Medical Home: A new model for medical care Edible marijuana — a half-baked idea? As more states legalize marijuana,… Medical alert systems: In vogue, and for some, invaluable. There is some scientific evidence for this benefit, such as the following article: Hi Joe, thank you for your comments. I agree that marijuana is safer than alcohol! Thank you for your interesting comment!
You mentioned two things. The other interesting thing is, is that we know that cannabidiol oil plays this amazing role in cancer. If you look at Dr. Most cancers, the majority of them, are not genetic in nature. This is an issue of the mitochondria being damaged, and now cancer cells are only using glucose, not ketones or fat.
My point is this; does the cannabidiol have its effect in cancer because of what it does for the mitochondria? Cancer — mitochondria and glucose related.
Research has really been going on into other areas. I said that repeatedly, but in cancer cells it becomes a different situation. You actually have—and the reason why cancer cells die and the way the body induces death in cancer cells, is an inflammatory reaction inside of the cancer cell.
It is actually inflammatory in cancer cells, leading to their demise, which is a great way to go. How does it do that? It gets the cell to die when it should have died, instead of adapting with this odd glycolysis or metabolism of sugar. If I could interject just a little bit. This is all from the Alzheimers.
What do you think, Daniel? Yeah, I think we definitely know some causative agents. We just discussed the glucose, right? We know that toxins can damage the mitochondria and cause this to become a problem. We know that heavy metals are involved. We know there are different environmental triggers.
I think glycoside plays a role. The common thread in almost all of this is inflammation. How do we quench that particular fire? Pompa, is that these things that we need to avoid.
That inflammation is key, and the immune cell seems to be very, very important in terms of producing those substances that cause inflammation.
Any of those things that we can use to avoid and reduce inflammation are very, very important and going back to fundamentals and lifestyle changes that need to be there. We have been ultra-successful with these cases where other people have not.
We like to put people on things like cannabidiol that are anti-inflammatory. We utilize things like intermittent fasting. We approach detox at a cellular level and particularly go after it in the brain.
This multi-therapeutic approach is something that I have found that really is the answer. You have to really get people to be compliant; however, it works.
Tell us a little bit about that. You brought up a very good point. You had said it. If my short-term memory starting going, I would definitely be looking for some things that down regulate inflammation.
I think it has an effect on the cell membrane and the receptor as well. Is there anything else? Some of the studies are showing this improved connectivity within the brain that there is modulation of those signals. Sometimes those modulation signals that are too strong get dampened, and sometimes those that are dampened or weakened are enhanced. The CBD molecule seems to be incredibly intelligent in terms of where it works on the body and on the mental faculties.
I like to think of it as an enhancer and a return to normalcy. Rather than cannabidiol being in the concept of the pharmaceutical industry, a drug that has to be applied and that has a linear relationship in terms of low levels having one effect and high levels being another effect, look at it as adjusting to being normal.
I like to think of it like that. My back hurt that much, so I loaded up. I probably had two or three in a little pile right there, and I put it under my tongue before I went to the airport.
I did the whole four-and-a-half hour flight. I had no pain. My wife was amazed, so I stayed the high level of CBD. It was really good. I noticed an absolute increase in my memory. Let me ask you. Of course it was an extraordinary experience, but could you see it as going back 20 years? I have that experience when my brain starts feeding from ketones.
I had the same experience when I started taking the higher levels of CBD. Some people get the same experience taking low levels, but for some reason when I took more, I definitely noticed this massive clarity in my brain, and yeah, I could describe it as being in my 20s perhaps in my brain.
I think my brain is sharper today than when I was in my 20s, doc. Honestly, I really do. Maybe you had those resources. Let me just say this. Contrast when people are smoking marijuana, obviously their brain slows down.
THC can actually start having a negative effect on the brain, I believe it driving inflammation. Some groups in different parts of the world are actually experimenting with exactly those percentages to find out what percentage of THC and CBD works the best. Meredith, you were asking about medical marijuana, and there was a question that came up on that.
What is it about medical marijuana that is special? The product that we carry on our website is the product that you like. Yeah, Meredith is holding it up right there. Go ahead and show that Meredith. Doc, I would like you to comment on some of the testimonies, the things that you see, because you use this so much with people and you have a lot of experience with it. I had not realized that some of these things could be reversed. I was just hoping to relieve suffering and pain, but when I saw a reversal, I was beside myself with amazement and surprise.
The first gentleman that I used cannabidiol on was an year-old man who was a veteran of the Korean War. He was lethargic sitting in his chair with type II diabetes. He was immobile, hardly moving, and hardly communicating.
Within a week of using fairly low levels of cannabidiol, he was activated. He was activated to the point of recalling all of his experiences with incredible designs in terms of finishing his book that he had started about his Korean War experiences in battle. He had incredible designs for going off and doing all the things that he had not been able to do, and he related to me some weeks later that during that time, he felt like he was a vegetable as he looks back on it, and with the cannabidiol, he woke up and knew the stuff that was going on.
There was some permanent damage that was there, but his conversation with me and his awareness of what was happening was there.
The Effects of Medical Marijuana on Alzheimer’s Treatment
This review will examine the intriguing promise that recent discoveries Keywords: cannabis, pain, brain tumor, epilepsy, Alzheimer disease, Parkinson . Although dose-response was tested, it is unclear that very low doses were .. combining THC and CBD, have been extremely helpful in treatment of. CBD has become a very popular item for people to take to help with a According to the Alzheimer's Association, here are 10 Early Symptoms of Alzheimer's: . This is an interesting study in that it occurred in live animals with fully treatment, it is clear that there is a very promising possibility that CBD. cannabidiol to reduce pain for anxiety relief for alzheimers disease and treatment a very intriguing and very real possibility in fact according to projectcbd over.